• Crit Care · Jan 2010

    Comment

    The kinetics of T regulatory cells in shock: beyond sepsis.

    • Eirini Christaki and Eleni Patrozou.
    • Division of Infectious Diseases, The Warren Alpert Medical School of Brown University, Providence, RI 02906, USA. eirini.christaki@gmail.com
    • Crit Care. 2010 Jan 1;14(2):132.

    AbstractDuring the past decade, there have been an increasing number of studies investigating the precise role of T regulatory cells in human disease. First recognized for their ability to prevent autoimmunity, T regulatory cells control effector CD4+ and CD8+ T lymphocytes and innate immune cells by several different suppressive mechanisms, like cell to cell contact, secretion of inhibitory cytokines and cytolysis. This suppressive function of T regulatory cells could contribute in a similar way to the profound immune dysfunction seen in critical illness whether the latter is due to sepsis or severe injury.

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