• Cheng Hean Lo, Jason N Brown, Eric J G Dantzer, MaitzPeter K MPKMBurns Unit, Concord Repatriation General Hospital, Hospital Road, Concord, NSW 2139, Australia. Electronic address: peter.maitz@sydney.edu.au., John G Vandervord, WagstaffMarcus J DMJDAdult Burns Service and Department of Plastic and Reconstructive Surgery, Royal Adelaide Hospital, Port Rd, Adelaide, SA 5000, Australia. Electronic address: m.wagstaff@doctors.org.uk., Timothy M Barker, and Heather Cleland.
• Victorian Adult Burns Service, The Alfred, 55 Commercial Rd, Melbourne, VIC 3004, Australia; Department of Surgery, Central Clinical School, Monash University, 99 Commercial Rd, Melbourne, VIC 3004, Australia. Electronic address: c.lo@alfred.org.au.
• Burns. 2022 May 1; 48 (3): 529-538.

IntroductionFor extensive burns, autologous donor skin may be insufficient for early debridement and grafting in a single stage. A novel, synthetic polyurethane dermal template (NovoSorb® Biodegradable Temporising Matrix, BTM) was developed to address this need. The aim of this study was to evaluate use of BTM for primary dermal repair after deep burn injury.MethodsA multicentre, prospective, clinical study was conducted from September 2015 to May 2018. The primary endpoint was % split skin graft take over applied BTM at 7-10 days after grafting. Secondary endpoints included % BTM take, incidence of infection and adverse events, and scar quality to 12 months after BTM application.ResultsThirty patients were treated with BTM and delayed split skin grafting. The % graft take had a mean of 81.9% and % BTM take had a mean of 88.6%, demonstrating effective integration of BTM. When managed appropriately, it was possible for BTM to integrate successfully despite findings suggestive of infection. Scar quality improved over time.DiscussionThese results provide additional clinical evidence on the safety and performance of BTM as an effective dermal substitute in the treatment of patients with deep burn injuries.Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

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