• Adv Exp Med Biol · Jan 2020

    Case Reports Multicenter Study

    Necrotizing Soft Tissue Infections: Case Reports, from the Clinician's Perspectives.

    • Torbjørn Nedrebø and Steinar Skrede.
    • Department of Anaesthesia, Haraldsplass Deaconess Hospital, Bergen, Norway. torbjorn.nedrebo@ihelse.net.
    • Adv Exp Med Biol. 2020 Jan 1; 1294: 21-37.

    AbstractNecrotizing soft tissue infections (NSTI) are rapidly spreading and life-threatening infections of skin and soft tissue. Essentially there are two types of NSTI, based on the invasive microorganisms. The speed of development and associated clinical features differ markedly depending on the bacterial etiology. Early recognition, extensive surgical debridement, and appropriate antimicrobials are pivotal for successful management. In this chapter, we present three cases from the INFECT-study population. This study was an international, multicenter, prospective cohort study of adult patients with NSTI. We describe the clinical presentations, pre-, peri-, and postoperative clinical findings, microbiology, and treatment in cases of monobacillary Streptococcus pyogenes necrotizing soft tissue infections NSTI, polymicrobial infection, and an unusual presentation of pelvic monobacillary S. pyogenes infection in an immunocompromised patient.

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