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Comparative Study Clinical Trial
Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements.
- Roland Wenzelburger, Florian Kopper, Bao-Rong Zhang, Karsten Witt, Wolfgang Hamel, Dieter Weinert, Johann Kuhtz-Buschbeck, Mukaddes Gölge, Michael Illert, Günther Deuschl, and Paul Krack.
- Department of Neurology, Christian-Albrechts Universität Kiel, Kiel, Germany.
- Mov. Disord. 2003 Oct 1; 18 (10): 1162-9.
AbstractDeep brain stimulation of the subthalamic nucleus (STN-DBS) reduces akinesia in Parkinson's disease but its impact on fine motor functions was unknown. We assessed the effects of DBS and a levodopa (L-dopa) test on the timing of the precision grip in 18 patients. Improvement on UPDRS-items reflecting hand functions and the shortening of the first phases of the precision grip were more distinct in the L-dopa test than in the pure STN-DBS condition. Other akinesia items and the time for build-up of lifting force were equally improved in both conditions. This suggests that routine STN-DBS might not be equally effective on all aspects of fine motor functions.Copyright 2003 Movement Disorder Society
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