• The Neurohospitalist · Oct 2016

    Cefepime-Associated SIRPIDs in a Patient With Normal Renal Function.

    • Emily Johnson, Yousef Hannawi, Nirma Carballido Martinez, and Eva K Ritzl.
    • Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
    • Neurohospitalist. 2016 Oct 1; 6 (4): 167-169.

    AbstractCefepime has been associated with encephalopathy and with nonconvulsive seizure activity, primarily in patients with renal impairment. Here, we report a case of cefepime-associated encephalopathy in a patient with normal renal function with stimulus-induced rhythmic activity seen on electroencephalogram, which resolved on discontinuation of cefepime. We bring this to the attention of the neurohospitalist community, as cefepime is widely used in the hospital setting, and cefepime-related neurotoxicity may go overlooked, especially in patients with normal renal function. Neurologists must recognize drug-related patterns, as the treatment is removing a medication rather than adding an antiepileptic medication.

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