• Eduardo Martin-Sanz, Juan Riestra, Laura Yebra, Alba Larran, Fiorella Mancino, Joaquin Yanes-Diaz, Maria Garrote, Marta Colmenero, Esther Montiel, Cristina Molina, Daniel Moreno, Antonio Rodriguez, Gerardo Monedero, Ricardo Sanz-Fernández, Rocio Gonzalez, and Jonathan Esteban-Sanchez.
• Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.
• Laryngoscope. 2020 Nov 1; 130 (11): 2674-2679.

ObjectiveTo evaluate the incidence of certain symptoms in a population of health workers exposed to coronavirus disease 2019 patients.Study DesignCase-control study.MethodsThe study was conducted at a tertiary care hospital from March 1 to April 7, 2020. Health workers with suspected coronavirus disease 2019 (COVID-19) infection were included. The presence of COVID-19 was detected by using real-time polymerase chain reaction (RT-PCR) methods. Positive and negative RT-PCR patients were used as case and control groups, respectively. This study analyzed the incidence of COVID-19 symptoms in both patient groups. Visual analog scales were used for self-assessment of smell and taste disorders, ranging from 0 (no perception) to 10 (excellent perception).ResultsThere were 215 (60.6%) patients with positive RT-PCR and 140 (39.4%) patients with negative RT-PCR. The presence of symptoms such as hyposmia hypogeusia, dysthermia, and cough were strongly associated with a positive RT-PCR. The association of cough and subjective hyposmia had 5.46 times higher odds of having a positive test. The receiver operating characteristic (ROC) analysis showed that a fever higher than 37.45°C resulted in sensitivity and specificity of 0.65 and 0.61, respectively. A total of 138 cases (64.1%) and 114 cases (53%) had subjective hyposmia and hypogeusia, respectively. The 85.4% of these patients recovered olfactory function within the first 14 days of the onset of the symptoms.ConclusionThere is a significant association between positive RT-PCR and subjective hyposmia. The association of subjective hyposmia and cough increase significantly the odds of having a positive RT-PCR. The measurement of fever as the only method for screening of COVID-19 infection resulted in a poor association.Level Of Evidence3 Laryngoscope, 130:2674-2679, 2020.© 2020 American Laryngological, Rhinological and Otological Society Inc, The Triological Society and American Laryngological Association (ALA).

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