• Manuel Alegre, Jon López-Azcárate, Fernando Alonso-Frech, Maria C Rodríguez-Oroz, Miguel Valencia, Jorge Guridi, Julio Artieda, and José A Obeso.
• Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain. malegre@unav.es
• Mov. Disord. 2012 Aug 1; 27 (9): 1178-81.

BackgroundDiphasic dyskinesias are a subtype of levodopa-induced dyskinesias that appear typically at the onset and end of levodopa antiparkinsonian action. The pathophysiology of diphasic dyskinesias is not well understood.MethodsWe analyzed local field potentials recorded from the subthalamic nucleus in 7 Parkinson's disease (PD) patients who showed typical diphasic dyskinesias during postoperative recordings through a deep brain stimulation electrode. The evolution of the different oscillatory activities related to the onset and end of diphasic dyskinesias was studied by windowed fast Fourier transforms.ResultsTypical "off"-state beta activity disappeared with the onset of diphasic dyskinesias, whereas gamma activity was absent or minimal until their end. Theta activity during diphasic dyskinesias was similar to that observed during peak-dose dyskinesias.ConclusionsFrom a neurophysiological viewpoint, patients exhibited oscillatory activity typical of the "on" medication state during diphasic dyskinesias. The minimal presence of gamma activity during diphasic dyskinesias, however, suggests that this "on" state might be incomplete or limited to dopaminergic mechanisms affecting the lower limbs.Copyright © 2012 Movement Disorder Society.

27 keywords...

hide…