• Toxicology letters · Oct 2013

    Neuroprotection by tetrahydroxystilbene glucoside in the MPTP mouse model of Parkinson's disease.

    • Lingling Zhang, LinHong Huang, Liangwei Chen, Dingjun Hao, and Jianzong Chen.
    • Department of Scientific Research, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710054, China.
    • Toxicol. Lett. 2013 Oct 24; 222 (2): 155-63.

    AbstractOur in vitro experiments suggested that tetrahydroxystilbene glucoside (TSG) affords a significant neuroprotective effect against MPP⁺-induced damage and apoptosis in PC12 cells though activation of the PI3K/Akt pathway. This study was aimed to investigate the potential neuroprotective effect of TSG in 1-methyl-4-phenyl-1,2,3,6-tetrahydropypridine (MPTP)-treated mouse model of Parkinson's disease (PD). We found that treatment of TSG protected dopaminergic neurons by preventing MPTP-induced decreases in substantia nigra tyrosine hydroxylase (TH)-positive cells and striatal dopaminergic transporter (DAT) protein levels. Furthermore, it was also associated with increasing striatal Akt and GSK3β phosphorylation, up-regulation of the Bcl-2/BAD ratio, and inhibition of the activation of caspase-9 and caspase-3. These results showed that TSG promoted dopamine neuron survival in vivo, the PI3K/Akt signaling pathway may have mediated the protection of TSG against MPTP, suggesting that TSG treatment might represent a neuroprotective treatment for PD.Crown Copyright © 2013. Published by Elsevier Ireland Ltd. All rights reserved.

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