• Erin Louise Doren and Melanie Lynn Aya-ay.
• Dr Doren is an Integrated Plastic Surgery Resident in the Department of Surgery, Division of Plastic Surgery, University of South Florida, Tampa, Florida.
• Aesthet Surg J. 2014 Mar 1; 34 (3): 394-9.

UnlabelledPyoderma gangrenosum (PG) is a rare, noninfectious, inflammatory dermatosis usually associated with autoimmune disorders. Wounds may mimic a necrotizing infection, and the diagnosis is usually made after antibiotic therapy fails. Debridement may cause even larger wounds because of pathergy, so PG treatment consists of corticosteroids and local wound care. Pyoderma gangrenosum can be a devastating complication of breast and aesthetic surgery. We describe a case of PG following unilateral breast reduction that resulted in systemic inflammatory response; after treatment with prednisone and topical tacrolimus, the PG was resolved. The application of topical tacrolimus may reduce the need for prolonged corticosteroids.Level Of Evidence5.

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