• Metab. Clin. Exp. · Apr 2015

    Review

    New aspects on the metabolic role of intestinal microbiota in the development of atherosclerosis.

    • Ioannis Drosos, Anna Tavridou, and George Kolios.
    • Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
    • Metab. Clin. Exp. 2015 Apr 1; 64 (4): 476-81.

    AbstractGut microbiota remains a very interesting, yet largely unexplored ecosystem inside the human organism. The importance of this ecosystem for the physiology and the pathophysiology of the organism is being slowly unraveled. Recent studies reveal a connection between intestinal microbiota and atherosclerosis development. It seems that alterations in the function and composition of this bacterial population lead through complex mechanisms to a high risk for atherosclerosis. Although these mechanisms remain largely unknown, published studies show that microbiota can lead to atherosclerosis either by augmenting known risk factors or via other, more "direct" mechanisms. This review article summarizes the available literature regarding this matter. Copyright © 2015 Elsevier Inc. All rights reserved.

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