• Louise M Stewart, C D'Arcy J Holman, Roger Hart, Judith Finn, Qun Mai, and David B Preen.
• School of Population Health, The University of Western Australia, Crawley, Western Australia, Australia. louise.stewart@uwa.edu.au
• Fertil. Steril. 2011 Apr 1; 95 (5): 1677-83.

ObjectiveTo measure IVF effectiveness, which is defined as the cumulative incidence of live delivery over real time in women after commencing IVF treatment.DesignPopulation-based retrospective cohort study.SettingIVF clinics in Western Australia (WA).Patient(S)All women ages 20-44 years inclusive at start of treatment, commencing IVF in 1982-1992 and 1993-2002 at clinics in WA (n = 8,275).Intervention(S)Data on IVF cycles were extracted from hospital records and a statutory reproductive technology register and linked to records of births.Main Outcome Measure(S)Cumulative incidence of an IVF-attributed live delivery and cumulative incidence of an IVF-attributed or IVF treatment-independent live delivery.Result(S)IVF effectiveness in the 1993-2002 cohort was 47% overall. It was highest in women ages 20-29 years at the start of treatment, measuring 58%; and 79% with the inclusion of IVF treatment-independent deliveries, and declined to 22% and 33%, respectively, in women ages 40-44 years. Couples underwent, on average, only three cycles, even though the cumulative probability of a live delivery increased with each successive cycle for at least the first five cycles.Conclusion(S)IVF effectiveness could be improved if women, particularly those over 35, underwent more cycles.Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

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