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Revista médica de Chile · Apr 2006
Case Reports[Antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis associated to the use of propylthiouracil. Report of four cases].
- Soledad Hidalgo V, Paulina Silva A, Fernanda Undurraga S, Néstor Soto I, and María Angélica Marinovic M.
- Departamentos de Endocrinología, Hospital Clínico San Borja Arriarán, Santiago de Chile. solehidalgo@manquehue.net
- Rev Med Chil. 2006 Apr 1; 134 (4): 475-80.
AbstractAntineutrophil cytoplasmic antibody (ANCA)-positive vasculitis is an uncommon complication of the use of propylthiouracil. When it occurs, it affects multiple organs as any systemic vasculitis. We report three females and one male, aged 30, 40, 43 and 41 years respectively, that after a lapse of 12 to 28 months of propylthiouracil use, presented clinical signs of vasculitis. All had high titers of ANCA against myeloperoxidase. In three patients, a skin biopsy confirmed the diagnosis. The condition subsided when propylthiouracil was discontinued, but one female patient required the use of prednisone.
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