• Thomas A Perry, Matthew J Parkes, Richard Hodgson, David T Felson, Terence W O'Neill, and Nigel K Arden.
• Arthritis Research UK Centre for Epidemiology, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, Research in Osteoarthritis Manchester (ROAM), Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, School of Biological Sciences, Stopford Building, Oxford Road, Manchester, M13 9PT, UK. thomas.perry@postgrad.man.ac.uk.
• Bmc Musculoskel Dis. 2019 Feb 14; 20 (1): 76.

BackgroundData from a recent clinical trial of vitamin D therapy in knee OA suggests that, compared to placebo, vitamin D therapy may be associated with a reduction in effusion-synovitis. Our aim was, using contrast-enhanced (CE) magnetic resonance imaging (MRI), to examine the effect of vitamin D therapy on synovial tissue volume (STV) and also subchondral bone marrow lesion (BML) volume in men and women with symptomatic knee OA.MethodsData was acquired from participants who took part in a randomised placebo-controlled trial (UK VIDEO) investigating the effect of vitamin D therapy (800 IU cholecalciferol daily) on radiographic joint space narrowing. A subsample had serial CE MRI scans acquired during the trial. Subjects with serial images were assessed (N = 50) for STV and subchondral BML volume. The difference in the mean change from baseline in these structural outcomes between intervention and placebo groups was assessed using random-effects modelling.ResultsThe mean age of the 50 subjects (24 active group, 26 placebo group) who contributed data to the analysis was 63.3 years (SD 6.5) and 74% were female. There was no significant difference at 2 years follow-up between the vitamin D and placebo groups in the mean change from baseline for STV (93.9 mm3, 95% CI -1605.0 to 1792.7) and subchondral BML volume (- 313.5 mm3, 95% CI -4244.7 to 3617.7).ConclusionsVitamin D supplementation does not appear to have an effect on synovitis or BML volume in patients with symptomatic knee OA.Trial RegistrationVIDEO was registered with EudraCT: ref. 2004-000169-37. The protocol for the trial can be accessed at https://www.ctu.mrc.ac.uk/studies/all-studies/v/video/.

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