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Mult Scler Relat Disord · Oct 2020
The multiple sclerosis (MS) drugs as a potential treatment of ARDS in COVID-19 patients.
- Malgorzata Kloc and Rafik M Ghobrial.
- The Houston Methodist Research Institute, Houston, TX 77030, USA; The Houston Methodist Hospital, Department of Surgery, Houston, TX, USA; The University of Texas, M.D. Anderson Cancer Center, Department of Genetics, Houston TX, USA. Electronic address: mkloc@houstonmethodist.org.
- Mult Scler Relat Disord. 2020 Oct 1; 45: 102437.
AbstractWe encourage studies on the effectiveness of multiple sclerosis drugs for the treatment of ARDS in COVID-19 infection. These drugs, through the inhibition of the RhoA/actin-dependent expression of virus receptors in the macrophages and macrophage recruitment to the lungs, have the potential to inhibit cytokine storm of lung macrophages, reduce or eliminate ARDS and improve the outcome of COVID-19 infection.Copyright © 2020 Elsevier B.V. All rights reserved.
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