• Thrombosis research · Jan 2015

    Performance of 18F fluoro-2-désoxy-D-glucose positron emission tomography/computed tomography for the diagnosis of venous thromboembolism.

    • Pierre-Yves Le Roux, Philippe Robin, Aurélien Delluc, Bernard Tardy, Ronan Abgral, Francis Couturaud, Abdelmalek Reffad, Grégoire Le Gal, and Pierre-Yves Salaun.
    • Université Européenne de Bretagne, Brest, France; Université de Brest, EA3878 (GETBO) IFR 148, Brest, France; CHRU de la Cavale Blanche, Service de médecine nucléaire, Boulevard Tanguy Prigent, 29609 Brest cedex, France. Electronic address: pierre-yves.leroux@chu-brest.fr.
    • Thromb. Res. 2015 Jan 1; 135 (1): 31-5.

    IntroductionThrombosis and inflammation are intimately linked. Inflammatory component of venous thromboembolism (VTE) may allow the use of FDG positron emission tomography / computed tomography (FDG PET/CT) in the detection of thrombotic process. Published studies remain limited and contradictory. We aimed at evaluating the performance of FDG PET/CT in the detection of VTE in a population of patients enrolled in a prospective study evaluating FDG PET/CT for cancer screening in etiological assessment of idiopathic VTE.Materials And MethodsThe first consecutive 100 patients who underwent FDG PET/CT were included. Visual and quantitative analyses of vascular axes was performed and compared with lower limb veins compression ultrasonography, lung scintigraphy and/or computed tomography pulmonary angiography.ResultsOut of the 100 patients, 63 presented lobar pulmonary embolism for a total of 217 embolic sites and 62 had a deep vein thrombosis for a total of 143 thrombotic sites. Regarding pulmonary embolism, sensitivity and specificity of FDG PET/CT were 3% (95%CI: 1-6%) and 99% (95%CI: 98-100%). SUV max ratio between pulmonary embolism location and non-pathological contralateral vessel was 1.04±0.18 (p=0.7). Regarding deep vein thrombosis, sensitivity and specificity were 31% (95%CI: 24-39%) and 88% (95%CI: 81-92%). The metabolic activity was significantly higher than in contralateral vessels (p<0.001), with a SUV max ratio of 1.25±0.53, but without any significant SUVmax threshold applicable in routine practice for deep vein thrombosis diagnosis.ConclusionsFDG PET/CT is not accurate enough for the diagnosis of VTE.Copyright © 2014 Elsevier Ltd. All rights reserved.

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