• Medicina clinica · Jul 2022

    Cardiopulmonary Exercise Testing in Patients with Post-COVID-19 Syndrome.

    • Leandro Barbagelata, Walter Masson, Diego Iglesias, Ezequiel Lillo, Juan Francisco Migone, Maria Laura Orazi, and Joaquin Maritano Furcada.
    • Cardiology Department, Hospital Italiano de Buenos Aires, Tte. Gral. Juan Domingo Perón 4190 (C1199ABB), Buenos Aires, Argentina. Electronic address: leandro-barbagelata@hotmail.com.
    • Med Clin (Barc). 2022 Jul 8; 159 (1): 6116-11.

    Background And AimSeveral reports have shown the persistence of long term symptoms after the initial COVID-19 infection (post-COVID-19 syndrome). The objective of this study was to analyze the characteristics of cardiopulmonary exercise testing (CPET) performed in patients with a history of COVID-19, comparing subjects according to the presence of post-COVID-19 syndrome.MethodsA cross-sectional study was performed. Consecutive patients >18 years with history of SARS-CoV-2 infection confirmed by polymerase chain reaction test and a CPET performed between 45 and 120 days after the viral episode were included. The association between variables related to CPET and post-COVID-19 syndrome was assessed using univariate and multivariate analysis.ResultsA total of 200 patients (mean age 48.8±14.3 years, 51% men) were included. Patients with post-COVID-19 syndrome showed significantly lower main peak VO2 (25.8±8.1mL/min/kg vs. 28.8±9.6mL/min/kg, p=0.017) as compared to asymptomatic subjects. Moreover, patients with post-COVID-19 syndrome developed symptoms more frequently during CPET (52.7% vs. 13.7%, p<0.001) and were less likely to reach the anaerobic threshold (50.9% vs. 72.7%, p=0.002) when compared to asymptomatic subjects. These findings were not modified when adjusting for confounders.ConclusionOur data suggest that post-COVID-19 syndrome was associated with less peak VO2, a lower probability of achieving the anaerobic threshold and a higher probability of presenting symptoms during the CPET. Future studies are needed to determine if these abnormalities during CPET would have prognostic value.Copyright © 2021 Elsevier España, S.L.U. All rights reserved.

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    This article appears in the collection: What is Long COVID?.

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