• Radiother Oncol · Jul 2008

    Comparative Study

    MRI-based preplanning in low-dose-rate prostate brachytherapy.

    • Osamu Tanaka, Shinya Hayashi, Masayuki Matsuo, Masahiro Nakano, Yasuaki Kubota, Sunaho Maeda, Kazuhiro Ohtakara, Takashi Deguchi, and Hiroaki Hoshi.
    • Department of Radiology, Gifu University School of Medicine, Japan. osa-mu@umin.ac.jp
    • Radiother Oncol. 2008 Jul 1; 88 (1): 115-20.

    PurposeTo compare the dosimetric results between MRI-based and TRUS-based preplanning in permanent prostate brachytherapy, and to estimate the accuracy of MRI-based preplanning by comparing with CT/MRI fusion-based postimplant dosimetry.Methods And MaterialsTwenty-one patients were entered in this prospective study with written informed consent. MRI-based and TRUS-based preplanning were performed. The seed and needle locations were identical according to MRI-based and TRUS-based preplanning. MRI-based and TRUS-based preplanning were compared using DVH-related parameters. Following brachytherapy, the accuracy of the MRI-based preplanning was evaluated by comparing it with CT/MRI fusion-based postimplant dosimetry.ResultsMean MRI-based prostate volume was slightly underestimated (0.73 cc in mean volume) in comparison to TRUS-based volume. There were no significant differences in the mean DVH-related parameters except with rectal V(100)(cc) between TRUS-based and MRI-based preplanning. Mean rectal V(100)(cc) was 0.74 cc in TRUS-based and 0.29 cc in MRI-based preplanning, respectively, and the values demonstrated a statistical difference. There was no statistical difference in mean rectal V(150)(cc), and rectal V(100)(cc) between MRI-based preplanning and CT/MRI fusion-based postimplant dosimetry.ConclusionProstate volume estimation and DVH-related parameters in MRI-based preplanning were almost identical to TRUS-based preplanning. From the results of CT/MRI fusion-based postimplant dosimetry, MRI-based preplanning was therefore found to be a reliable and useful modality, as well as being helpful for TRUS-based preplanning. MRI-based preplanning can more accurately predict postimplant rectal dose than TRUS-based preplanning.

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