• Atsushi Arai, Masamitsu Nishihara, Takashi Sasayama, Hideo Aihara, Kohkichi Hosoda, Tomoo Itoh, Yoshio Sakagami, Keiichi Kuwamura, and Eiji Kohmura.
• Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
• Neurol. Med. Chir. (Tokyo). 2010 Jan 1;50(6):488-91.

AbstractA 55-year-old woman presented with a rare xanthogranuloma of the sellar region after complaining of severe headache and visual disturbance 3 months previously. Clinical examination showed she was alert with early signs of bitemporal hemianopsia. Endocrinological examination revealed hypopituitarism. Magnetic resonance imaging showed an intrasellar mass extending into the suprasellar region and compressing the optic chiasma, which appeared homogeneously hyperintense on T(1)-weighted images. Endonasal transsphenoidal resection of the tumor was performed. Histological examination disclosed granulomatous tissue with cholesterol clefts, hemosiderin deposits, fibrous tissues, and macrophages containing rich fat. The histological diagnosis was xanthogranuloma of the sellar region. Her visual symptoms recovered postoperatively although the hypopituitarism remained. Xanthogranuloma of the sellar region is rare, but must be considered in the differential diagnosis of tumors of the sellar region.

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