• J Rheumatol · Dec 1997

    Case Reports

    Cyclophosphamide induced water intoxication in a woman with Sjögren's syndrome.

    • A Spital and S Ristow.
    • Division of Nephrology, Genesee Hospital, University of Rochester School of Medicine, New York 14607, USA.
    • J Rheumatol. 1997 Dec 1; 24 (12): 2473-5.

    AbstractWater intoxication is a well described complication of high dose intravenous (i.v.) cyclophosphamide therapy combined with forced hydration. Less well known is that water intoxication can develop even after low dose iv cyclophosphamide. To draw attention to this potentially life threatening complication, we describe a woman who developed acute water intoxication after treatment with low dose iv cyclophosphamide for a sensory neuropathy secondary to Sjögren's syndrome. Rheumatologists should be aware of this serious adverse effect of iv cyclophosphamide because this drug is being used increasingly for treatment of a variety of rheumatological diseases. The pathogenesis, clinical characteristics, treatment, and methods for prevention of cyclophosphamide induced water intoxication are discussed.

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