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- Akihito Kawazoe and Kohei Shitara.
- Dept. of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East.
- Gan To Kagaku Ryoho. 2017 Sep 1; 44 (9): 717-721.
AbstractIt has been reported that favorable influences of cytotoxic agents to anti-tumor immune response included immunogenic cell death and suppression of regulatory T cell and myeloid-derived suppressor cell. Some clinical trials showed that the addition of immune checkpoint inhibitor to standard chemotherapy improved efficacy in patients with non-small-cell lung cancer or malignant melanoma in first-line settings. Phase III trials of the combination of immune checkpoint inhibitor and chemotherapy in several malignancies are ongoing.
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