• Azwa Shamsuddin, Mark Jeffries, Aziz Sheikh, Libby Laing, Nde-Eshimuni Salema, Anthony J Avery, Antony Chuter, Justin Waring, and Richard N Keers.
• Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK azwashamsuddin88@gmail.com.
• BJGP Open. 2021 Oct 1; 5 (5).

BackgroundWhile the use of prescribing safety indicators (PSI) can reduce potentially hazardous prescribing, there is a need to identify actionable strategies for the successful implementation and sustainable delivery of PSI-based interventions in general practice.AimTo identify strategies for the successful implementation and sustainable use of PSI-based interventions in routine primary care.Design & SettingQualitative study in primary care settings across England.MethodAnchoring on a complex pharmacist-led IT-based intervention (PINCER) and clinical decision support (CDS) for prescribing and medicines management, a qualitative study was conducted using sequential, multiple methods. The methods comprised documentary analysis, semi-structured interviews, and online workshops to identify challenges and possible solutions to the longer-term sustainability of PINCER and CDS. Thematic analysis was used for the documentary analysis and stakeholder workshops, while template analysis was used for the semi-structured interviews. Findings across the three methods were synthesised using the RE-AIM (reach, efficacy, adoption, implementation, and maintenance) framework.ResultsForty-eight documents were analysed, and 27 interviews and two workshops involving 20 participants were undertaken. Five main issues were identified, which aligned with the adoption and maintenance dimensions of RE-AIM: fitting into current context (adoption); engaging hearts and minds (maintenance); building resilience (maintenance); achieving engagement with secondary care (maintenance); and emphasising complementarity (maintenance).ConclusionExtending ownership of prescribing safety beyond primary care-based pharmacists, and achieving greater alignment between general practice and hospital prescribing safety initiatives, is fundamental to achieve sustained impact of PSI-based interventions in primary care.Copyright © 2021, The Authors.

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