• Cochrane Db Syst Rev · Aug 2021

    Review

    Rituximab for eradicating inhibitors in people with acquired haemophilia A.

    • Tracey Remmington and Sherie Smith.
    • Department of Women's and Children's Health, University of Liverpool, Liverpool, UK.
    • Cochrane Db Syst Rev. 2021 Aug 23; 8 (8): CD011907CD011907.

    BackgroundAcquired haemophilia A is a rare bleeding disorder caused by the development of specific autoantibodies against coagulation factor VIII. Standard treatment, usually steroids alone, or in combination with cyclophosphamide, aims to stop acute bleeds by using haemostatic agents to promote clotting. Rituximab may be an alternative approach to the treatment of acquired haemophilia by eradicating FVIII autoantibodies. This is an update of a previously published Cochrane Review.ObjectivesTo assess the efficacy and adverse effects of rituximab for treating people with acquired haemophilia A.Search MethodsWe searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's trials registers, comprising references identified from comprehensive electronic database searches and handsearches of relevant journals and conference proceedings (January 2021). We also undertook searches of CENTRAL, MEDLINE and online trial registries (January 2021).Selection CriteriaRandomised and quasi-randomised controlled trials of rituximab for people with acquired haemophilia A, with no restrictions on gender, age or ethnicity.Data Collection And AnalysisNo trials matching the selection criteria were eligible for inclusion.Main ResultsNo trials matching the selection criteria were eligible for inclusion.Authors' ConclusionsWe found no randomised clinical trials of rituximab for acquired haemophilia A. Thus, we are not able to draw any conclusions or make any recommendations on rituximab for eradicating inhibitors in people with acquired haemophilia A based on the highest quality evidence. Given that undertaking randomised controlled trials in this field is a complex task, we suggest that, while planning such trials, clinicians treating the disease continue to base their choices on alternative, lower-quality sources of evidence. In a future update of this review, we plan to appraise and incorporate eligible randomised controlled trials, as well as other high-quality, non-randomised studies.Copyright © 2021 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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