• Exp Ther Med · Dec 2015

    Novel antiepileptic drug lacosamide exerts neuroprotective effects by decreasing glial activation in the hippocampus of a gerbil model of ischemic stroke.

    • Ji Yun Ahn, Bing Chun Yan, Joon Ha Park, Ji Hyeon Ahn, Dae Hwan Lee, In Hye Kim, Jeong-Hwi Cho, Bai Hui Chen, Jae-Chul Lee, Young Shin Cho, Myoung Chul Shin, Jun Hwi Cho, Seongkweon Hong, Moo-Ho Won, and Sung Koo Kim.
    • Department of Emergency Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon 200-701, Republic of Korea ; Department of Emergency Medicine, Sacred Heart Hospital, College of Medicine, Hallym University, Anyang, Gyeonggi 431796, Republic of Korea.
    • Exp Ther Med. 2015 Dec 1; 10 (6): 2007-2014.

    AbstractLacosamide, which is a novel antiepileptic drug, has been reported to exert various additional therapeutic effects. The present study investigated the neuroprotective effects of lacosamide against transient cerebral ischemia-induced neuronal cell damage in the hippocampal cornu ammonis (CA)-1 region of a gerbil model. Neuronal Nuclei immunohistochemistry demonstrated that pre- and post-surgical treatment (5 min ischemia) with 25 mg/kg lacosamide protected CA1 pyramidal neurons in the lacosamide-treated-ischemia-operated group from ischemic injury 5 days post-ischemia, as compared with gerbils in the vehicle-treated-ischemia-operated group. Furthermore, treatment with 25 mg/kg lacosamide markedly attenuated the activation of astrocytes and microglia in the ischemic CA1 region at 5 days post-ischemia. The results of the present study suggested that pre- and post-surgical treatment of the gerbils with lacosamide was able to protect against transient cerebral ischemic injury-induced CA1 pyramidal neuronal cell death in the hippocampus. In addition, the neuroprotective effects of lacosamide may be associated with decreased activation of glial cells in the ischemic CA1 region.

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