• Clin Cancer Res · Feb 2012

    Impact of genomics on personalized cancer medicine.

    • Carlos L Arteaga and José Baselga.
    • Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6307, USA. carlos.arteaga@vanderbilt.edu
    • Clin Cancer Res. 2012 Feb 1; 18 (3): 612-8.

    AbstractRecent advances in tumor genetics and drug development have led to the generation of a wealth of anticancer targeted therapies. A few recent examples indicate that these drugs are mainly, if not exclusively, active against tumors of a particular genotype that can be identified by a diagnostic test, usually by detecting a somatic alteration in the tumor DNA. However, for the majority of targeted therapies in development, there are still no clinical tools to determine which patients are most likely to benefit or, alternatively, be resistant de novo to these novel agents or drug combinations.

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