• Internal medicine journal · Mar 2018

    Case Reports

    Severe methanol poisoning with neurological sequelae: implications for diagnosis and management.

    • Nicolette R Holt and Christopher P Nickson.
    • Department of General Internal Medicine, Alfred Hospital, Melbourne, Victoria, Australia.
    • Intern Med J. 2018 Mar 1; 48 (3): 335-339.

    AbstractA 22-year-old woman presented with methanol toxicity manifesting as headache, reduced conscious state and visual change after consuming home-made grappa. She progressed to a coma with fixed mydriasis and severe acidaemia (pH 6.55). She was treated with empirical antidote administration (intravenous ethanol) and enhanced elimination through haemodialysis. She survived despite her delayed presentation but developed significant neurological sequelae, including visual impairment. We provide an overview of key elements of diagnosis and recent updates in treatment recommendations.© 2018 Royal Australasian College of Physicians.

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