• Matías Alet, Celina Ciardi, Alberto Alemán, Lucrecia Bandeo, Pablo Bonardo, Clarisa Cea, Juan Cirio, Jerónimo Cossio, María Cuculic, María Martha Esnaola, Fernando García-Pérez, Federico Giner, Maia Gómez-Schneider, Cristian Isaac, Sandra Lepera, Carlos Martínez, Román Martínez-Lorenzín, Mariana Montes, Gabriela Orzuza, Gabriel Persi, Guillermo Povedano, Virginia Pujol-Lereis, Julieta Quiroga-Narváez, Marina Romano, Rodrigo Sabio, Juan Viglione, María Cristina Zurrú, Gustavo Saposnik, and Argentinian Stroke and Cerebrovascular Diseases Study Group - Argentine Neurological Society.
• Centro Integral de Neurología Vascular, FLENI. Ciudad Autónoma de Buenos Aires, Argentina; Hospital General de Agudos J. M. Ramos Mejía. Ciudad Autónoma Buenos Aires, Argentina. Electronic address: malet@fleni.org.ar.
• J Stroke Cerebrovasc Dis. 2020 Oct 1; 29 (10): 105145.

BackgroundCerebral venous thrombosis (CVT) is a rare medical condition that primarily affects young adults. The clinical spectrum is broad and its recognition remains a challenge for clinicians. Limited information is available on CVT in Argentina. Our goal was to report the results of the first National registry on CVT in Argentina and to compare clinical presentation, predisposing factors and outcomes with other international registries.Material And MethodThe Argentinian National Registry on CVT (ANR-CVT) is a multicenter retrospective cohort study comprising patients aged 18 and older with a diagnosis of CVT from January 2015 to January 2019. We evaluated demographics, predisposing factors, clinical presentation, and radiological characteristics (e.g. number of involved sinuses, venous infarction or hemorrhage on CT and MRI scans at admission), therapeutic interventions and functional outcomes at discharge and at 90 days. Our results were compared to a literature review of CVT registries.ResultsOverall, one hundred and sixty-two patients met the inclusion criteria. The mean age was 42 (±17) years; 72% were women. Seventy percent of patients were younger than 50 years. The most common presenting symptom was headache (82%). The transverse sinus was the most common site of thrombosis (70%) followed by the sigmoid sinus (46%). The main predisposing factor in women was contraceptive use (44%), 3% of the events occurred during pregnancy and 9% during the puerperium. Participants 50 years and older had a higher frequency on malignancy related (7.5% vs. 30%, p = 0.0001) and infections (2% vs. 11%, p = 0.001). The modified Rankin Scale (mRS) ≤2 at discharge was 81% and the rate of mortality at discharge was 4%. At 90 days, the mRS≤2 was 93%. When the ANR-CVT was compared with larger registries from Europe and Asia, the prevalence of cancer among patients with CVT was two to five-fold higher (15% vs. 7% and 3%, respectively; p = 0.002 and p < 0.001). Anticoagulation rates at discharge were also higher (94%) compared to registries from Asia (ASCVT - 68%) or Turkey (VENOST - 67%).ConclusionParticipants in the first ANR-CVT had a low mortality and disability at 90 days. Clinical and radiological characteristics were similar to CVT from other international registries with a higher prevalence of cancer. There was a high variability in treatment adherence to guidelines as reflected by anticoagulation rates (range 54.5%-100%) at discharge.Copyright © 2020 Elsevier Inc. All rights reserved.

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