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J. Am. Coll. Cardiol. · Sep 2014
ReviewPrevention of anthracycline-induced cardiotoxicity: challenges and opportunities.
- Pimprapa Vejpongsa and Edward T H Yeh.
- The University of Texas MD Anderson Cancer Center, Houston, Texas.
- J. Am. Coll. Cardiol. 2014 Sep 2; 64 (9): 938-45.
AbstractAnthracycline compounds are major culprits in chemotherapy-induced cardiotoxicity, which is the chief limiting factor in delivering optimal chemotherapy to cancer patients. Although extensive efforts have been devoted to identifying strategies to prevent anthracycline-induced cardiotoxicity, there is little consensus regarding the best approach. Recent advances in basic mechanisms of anthracycline-induced cardiotoxicity provided a unified theory to explain the old reactive-oxygen species hypothesis and identified topoisomerase 2β as the primary molecular target for cardioprotection. This review outlines current strategies for primary and secondary prevention of anthracycline-induced cardiotoxicity resulting from newly recognized molecular mechanisms and identifies knowledge gaps requiring further investigation. Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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