• Serene Ho and Adrian Wong.
• Cavendish Clinic London.
• Curr Opin Anaesthesiol. 2021 Oct 1; 34 (5): 582-589.

Purpose Of ReviewGiven the number of drugs available in the anaesthetist's armamentarium, drug interactions need to be managed. This is particularly true of psychoactive medications which primarily act on the central nervous system, targeting neurotransmitter pathways often affected by anaesthetic agents. This review gives an overview of the potential interactions of commonly used psychoactive medications with anaesthetic agents and hence their perioperative considerations. As anaesthetists will already be very familiar with the benzodiazepines, they will not be discussed here. Electroconvulsive therapy will also not be discussed.Recent FindingsA wide range of psychoactive medications can interact with drugs commonly used in perioperative care including anaesthetic agents. There is limited clinical research into their effects and hence these interactions are based on known pharmacological actions.SummaryA cautious, pragmatic approach is recommended when managing patients on psychoactive medications requiring anaesthesia as part of their medical care.Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

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