• Internal medicine · Mar 2022

    Case Reports

    Amelanotic Malignant Melanoma with a BRAF V600E Mutation Mimicking Primary Lung Cancer.

    • Reiko Matsuzawa, Masahiro Morise, Ichidai Tanaka, Shunsaku Hayai, Yutaro Tamiya, Junji Koyama, Tetsunari Hase, Keiko Wakahara, Deoksu Kim, Yoshie Shimoyama, and Naozumi Hashimoto.
    • Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Japan.
    • Intern. Med. 2022 Mar 1; 61 (5): 703-708.

    AbstractAmelanotic melanoma is a rare type of melanoma that shows little or no melanin pigmentation. When tumor lesions are not detected in cutaneous sites, the presence of melanin is the hallmark sign of malignant melanoma. We herein report a case of amelanotic melanoma with a BRAF V600E mutation mimicking primary lung cancer that was finally diagnosed on an autopsy. The current case suggests important caveats for the differential diagnosis of patients with BRAF V600E mutation-positive poorly differentiated lung tumors. In terms of the pathological diagnosis, routine immunohistochemical staining may be useful, especially in patients with a poorly differentiated lung tumor without TTF-1 expression.

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.