• Hajime Iwasaki, Shunichi Takagi, Osamu Kitajima, Yukino Oshima, Sarah Kyuragi Luthe, and Takahiro Suzuki.
• Department of Anesthesiology, Nihon University School of Medicine, 30-1, Oyaguchi Kamicho, Itabashi-Ku, Tokyo, 173-8610, Japan. iwasaki.hajime@nihon-u.ac.jp.
• J Clin Monit Comput. 2022 Aug 1; 36 (4): 1213-1217.

PurposeThe aim of the study was to evaluate the plasma rocuronium concentration in autologous blood transfusion obtained from the cell salvage (CS) system following cardiac surgery with cardiopulmonary bypass (CPB).MethodsThis prospective observational study was conducted in a university teaching hospital from July to November 2020. Patients undergoing general anesthesia for cardiac surgery with CPB were enrolled in the study. After separation from CPB, residual blood remaining in the extracorporeal system was collected as the control sample. The second sample (CS blood) was collected from the autologous blood transfusion obtained after completion of the CS system with Cell Saver® Elite®. Hematocrit values of both samples were also examined.ResultsTen subjects (aged 57-86 years) were enrolled in this study. Plasma rocuronium concentrations (ng/ml) were significantly lower in the CS blood (94.0 ± 77.5) compared to the control (2950 ± 812.2) (p = 0.002). Hematocrit values (%) were significantly higher in the CS blood (75.2 ± 11.3) compared to the control (40.2 ± 10.2) (p = 0.002).ConclusionAutologous blood transfusion obtained from CS system following cardiac surgery with CPB, only retained a small amount of plasma rocuronium concentration, therefore, the risk of autologous blood transfusion contributing to clinically relevant residual neuromuscular blockade postoperatively should be considered to be low.Trial RegistrationThis trial was registered in the University Hospital Medical Information Network under registration number UMIN000040877 (registration date; June 24, 2020).© 2021. The Author(s), under exclusive licence to Springer Nature B.V.

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