• Best Pract Res Clin Haematol · Sep 2007

    Review

    Chemoimmunotherapy of chronic lymphocytic leukemia.

    • Constantine S Tam and Michael J Keating.
    • Leukemia Department, Unit 428, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77025, USA.
    • Best Pract Res Clin Haematol. 2007 Sep 1;20(3):479-98.

    AbstractThe past two decades have seen a major paradigm shift in the therapy of chronic lymphocytic leukemia (CLL), with the treatment goal shifting from symptom palliation to the attainment of maximal disease control using the most effective frontline regimens available, thus prolonging survival and possibly leading to cure. The most potent therapeutic regimens developed to date include the chemoimmunotherapy combinations incorporating purine analogs and monoclonal antibodies. We review the evolution of modern chemoimmunotherapy for CLL, and discuss current research directions for further refining the potency of these regimens.

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