• Revue médicale suisse · Nov 2011

    Review

    [Inhaled therapies for cystic fibrosis].

    • Samir Lahzami and Laurent P Nicod.
    • Service de pneumologie, Département de médecine, CHUV, 1011 Lausanne. Samir.Lahzami@chuv.ch
    • Rev Med Suisse. 2011 Nov 23; 7 (318): 2285-8.

    AbstractInhaled therapies play a significant role in the management of cystic fibrosis patients. Mucolytic and airway-rehydrating agents improve mucociliary clearance and respiratory functional status. Nebulized antibiotherapy achieve high local concentration, while reducing systemic toxicity. Tolerance to inhaled treatments is good excepting frequent bronchoconstriction which can usually be prevented by prior administration of beta2-mimetics. The majority of treatments are only available in liquid formulations. Thus, nebulization is the most frequently used inhalation mode. Vibrating-mesh nebulizers have significantly reduced inhalation time.

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