• Monika Kristaq Belba, Laerta Eduard Kakariqi, and Amy Gjergji Belba.
• Department of Biomedical and Experimental Courses, Field of Science: Pharmacology, Faculty of Medicine, University of Medicine, Tirana, Albania; Department of Surgery, Service of Burns and Plastic Surgery, Service of Anesthesiology, University Hospital Center "Mother Teresa", Tirana, Albania; Department of Anesthesia and Intensive Care, KULeuven, Belgium. Electronic address: piet_amy@yahoo.com.
• Burns. 2021 Sep 1; 47 (6): 1274-1284.

IntroductionEfforts with the utilization of an Input/Output ratio (I/O ratio) are done with success for analyzing and moving forward the treatment in the resuscitation phase of the burn patient. The need for conducting this research is to apply the I/O ratio in our cohort as a helpful index for classifying the resuscitation response of the burn patients. Our prespecified hypothesis is if it matters the analysis of the I/O ratio at 8 h of fluid resuscitation period.Material And MethodThis prospective observational study was performed in 50 patients (22 adults and 28 children) admitted in the Intensive Care of the Service of Burns in Tirana, Albania in the period January to December 2016. We calculated the I/O ratio at 8 h and the end of the 1st 24 h based on the stratification of patients according to the ratio in respective groups. In the adult population we did an analysis whereby the ratio I/O at 8 h has a relationship with the 24 h results as well as with ICU-free days.ResultsThe 24 h fluid resuscitation was done with the majority clustered in the range 2-4 ml/kg/% TBSA with fluid-weight score (ml/kg) correlated with % TBSA. After calculation of the I/O ratio at 8 h, 29 patients were assigned in over-responders (<0.166), 16 patients in the expected group(0.166-0.334), and 5 patients were assigned in under-responders (>0.334). There is a strong correlation between the I/O ratio at 8 h and the I/O ratio at 24 h and I/O ratio predict better the longer ICU-free days.ConclusionsThe I/O ratio is a very useful parameter not only at 12 h and 24 h but also at 8 h after burns. By classifying the patients into outcome groups that reflect not only the volume given but moreover the physiologic reactions to the resuscitation volume gotten, we were more attentive to patients in under-responders at 8 h. This parameter fulfills the criteria for better classifying patients and a better understanding of the physiology of burns.Copyright © 2021 Elsevier Ltd and ISBI. All rights reserved.

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