• Oncology Ny · Jan 2007

    Review

    Optimizing endocrine therapy for premenopausal and postmenopausal women with breast cancer.

    • Mary Cianfrocca and Antonio C Wolff.
    • Division of Hematology/Oncology, Northwestern University, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois 60611, USA. mcianfrocca@northwestern.edu
    • Oncology Ny. 2007 Jan 1; 21 (1): 63-9; discussion 69, 72, 75 passim.

    AbstractThe majority of invasive breast cancer patients present with hormone receptor-positive disease, and modulation of estrogen receptor (ER) activation is an essential component of systemic adjuvant therapy for these women. While tamoxifen has traditionally been the primary adjuvant endocrine therapy for all ER-positive women, recent trials evaluating the use of aromatase inhibitors (AIs) have challenged this standard in postmenopausal women, and ongoing trials are examining the optimal use of endocrine therapy in younger women. Issues regarding the optimal approach to endocrine therapy in both pre- and postmenopausal women are examined in this review.

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