• Bernard Schachtel, Adrian Shephard, Emily Schachtel, Mary Beth Lorton, Tim Shea, and Sue Aspley.
• Schachtel Research Company Inc., Jupiter, FL 33477, USA.
• Pain Manag. 2018 Mar 1; 8 (2): 85-94.

AimPatients with pharyngitis often describe various sensory, affective and evaluative pain qualities. Using an 11-word/phrase index, the Qualities of Sore Throat Index (QuaSTI), we characterized throat symptoms and evaluated changes in a randomized controlled trial (NCT01986361).Materials & MethodsPatients received a single flurbiprofen 8.75 mg (n = 101) or placebo (n = 21) lozenge and rated throat soreness at baseline and regular intervals over 3 h, and the QuaSTI at baseline, 1, 2 and 3 h post-treatment.ResultsThe QuaSTI distinguished active drug from placebo and detected clinically important (≥2-point) changes over 3 h. Mean change from baseline over 3 h was significantly greater for flurbiprofen (154%) than placebo (p < 0.05).ConclusionThe QuaSTI is a sensitive instrument for measuring therapeutic effects in patients with pharyngitis.

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