• Wei-Syun Hu and Cheng-Li Lin.
• School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan; Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital, Taichung 40447, Taiwan. Electronic address: weisyunhu@gmail.com.
• Atherosclerosis. 2017 Nov 1; 266: 205-211.

Background And AimsThe current study was conducted to assess the ability of CHA2DS2-VASc, CHADS2 and HATCH scores in predicting new-onset atrial fibrillation (AF) among patients with cancer.MethodsPatients with newly diagnosed cancer between 1 January, 2000 and 31 December, 2011, from the Registry for Catastrophic Illness Patient Database, were defined as the study cohort. CHA2DS2-VASc, CHADS2 and HATCH scores were used for new-onset AF prediction in these study patients, and the predictive accuracy of the scores was assessed by the receiver operating characteristics (ROC) curve.ResultsA total of 760,339 cancer patients were identified as the study participants. The ROC curves were 0.68 (95% confidence interval [CI] = 0.68-0.69) for the CHA2DS2-VASc score, 0.67 (95% CI = 0.67-0.68) for the CHADS2 score and 0.69 (95% CI = 0.69-0.70) for the HATCH score. There were significant differences of c-statistics among CHA2DS2-VASc score, CHADS2 score and HATCH score (CHA2DS2-VASc score vs. CHADS2 score, p = 0.01; CHA2DS2-VASc score vs. HATCH score, p = 0.002; CHADS2 score vs. HATCH score, p < 0.001).ConclusionsThe current study is the first to assess the prognostic value of 3 AF risk scores (CHA2DS2-VASc, CHADS2 and HATCH scores) in patients with newly-diagnosed cancer. HATCH score was found to have a slightly but significantly better predictive performance than the other 2 scores.Copyright © 2017 Elsevier B.V. All rights reserved.

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