• Infect. Dis. Clin. North Am. · Jun 1999

    Review

    Nitric oxide in the pathogenesis of sepsis.

    • S Symeonides and R A Balk.
    • Section of Critical Care Medicine, Rush Medical College and, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA.
    • Infect. Dis. Clin. North Am. 1999 Jun 1; 13 (2): 449-63, x.

    AbstractIn sepsis and septic shock, inflammatory mediators result in the production of increased concentrations of nitric oxide (NO) from the enzymatic breakdown of the amino acid L-arginine. The increased amounts of NO are responsible for changes in vasomotor tone, decreased vasopressor responsiveness, and decreased myocardial function, characteristic of septic insult. Therapeutic strategies designed to reduce the concentration of NO by inhibiting the action of the nitric oxide synthase enzyme, or by scavenging the excess NO, offer the potential to treat directly the vasomotor abnormalities and myocardial depression seen in sepsis and other inflammatory states. This article reviews the biology of NO in sepsis and discusses strategies for neutralization of the increased NO production, in the setting of severe sepsis and septic shock.

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