• Mehmet Nuri Yakar, Begüm Ergan, Bişar Ergün, Murat Küçük, Ali Cantürk, Mahmut Cem Ergon, Naciye Sinem Gezer, Erdem Yaka, Bilgin Cömert, and Ali Necati Gökmen.
• Division of Intensive Care,Department of Anaesthesiology and Reanimation, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey.
• Turk J Med Sci. 2021 Oct 21; 51 (5): 228522952285-2295.

BackgroundTo date, the coronavirus disease 2019 (COVID-19) caused more than 2.6 million deaths all around the world. Risk factors for mortality remain unclear. The primary aim was to determine the independent risk factors for 28-day mortality.Materials And MethodsIn this retrospective cohort study, critically ill patients (≥ 18 years) who were admitted to the intensive care unit due to COVID-19 were included. Patient characteristics, laboratory data, radiologic findings, treatments, and complications were analyzed in the study.ResultsA total of 249 patients (median age 71, 69.1% male) were included in the study. 28-day mortality was 67.9% (n = 169). The median age of deceased patients was 75 (66–81). Of them, 68.6% were male. Cerebrovascular disease, dementia, chronic kidney disease, and malignancy were significantly higher in the deceased group. In the multivariate analysis, sepsis/septic shock (OR, 15.16, 95% CI, 3.96–58.11, p < 0.001), acute kidney injury (OR, 4.73, 95% CI, 1.55–14.46, p = 0.006), acute cardiac injury (OR, 9.76, 95% CI, 1.84–51.83, p = 0.007), and chest CT score higher than 15 (OR, 4.49, 95% CI, 1.51-13.38, p = 0.007) were independent risk factors for 28-day mortality.ConclusionEarly detection of the risk factors and the use of chest CT score might improve the outcomes in patients with COVID-19.This work is licensed under a Creative Commons Attribution 4.0 International License.

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