• Microbes and infection · Nov 2004

    IL-1 receptor-associated kinase 1 mediates protection against Staphylococcus aureus infection.

    • Margareta Verdrengh, James A Thomas, and Olof H Hultgren.
    • Department of Rheumatology and Inflammation Research, Göteborg University, Guldhedsgatan 10 A, S-413 46 Göteborg, Sweden. margareta.verdrengh@rheuma.gu.se
    • Microbes Infect. 2004 Nov 1; 6 (14): 1268-72.

    AbstractThe interleukin-1 receptor-associated kinase-1 (IRAK-1) mediates signal transduction from Toll-like/IL-1/IL-18 receptors. Though a critical protective role against Staphylococcus aureus infection has been previously attributed to myeloid differentiation factor 88 (MyD88) and IRAK-4, both also involved in TLR/IL-1/IL-18 signaling, the role of IRAK-1 is unknown. IRAK-1-deficient (IRAK-1-/-) and wild-type mice were inoculated i.v. with 2 x 10(7) or 1 x 10(6) S. aureus per mouse to evaluate the role of IRAK-1 in S. aureus sepsis. Since IRAK-1 transduces IL-1R signals, IL-1R-/- mice were also included in experiments. IRAK-1-/- mice are susceptible to a high dose of S. aureus compared to wild-type controls. In contrast to the high mortality and extensive weight loss seen in IL-1R-deficient mice in response to 1 x 10(6) S. aureus, IRAK-1-/- mice are resistant to this low dose of S. aureus. Thus IRAK-1 plays an important role in the host response to staphylococcal sepsis.

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