• Eur. J. Pediatr. · Aug 1995

    Case Reports

    Ketamine and strychnine treatment of an infant with nonketotic hyperglycinaemia.

    • H Tegtmeyer-Metzdorf, B Roth, M Günther, M Theisohn, U Heinemann, H A Adams, and G Sticht.
    • Klinik und Poliklinik für Kinderheilkunde, Universität Köln, Germany.
    • Eur. J. Pediatr. 1995 Aug 1; 154 (8): 649-53.

    UnlabelledNon-ketotic hyperglycinaemia (NKH) is a severe seizure disorder associated with high glycine levels. Glycine is a major inhibitory neurotransmitter in the CNS, but has also modulating effects at one of the glutamate receptors, the N-methyl-D-aspartate-(NMDA) receptor. Based on this knowledge we treated a female newborn suffering from severe NKH with the NMDA receptor blocker ketamine in association with strychnine and magnesium supplementation. This treatment led to cessation of seizures, reappearance of swallowing and sucking and improved the neurological status. Some pharmacokinetic data of strychnine and ketamine in the infant are given.ConclusionKetamine in combination with strychnine may be beneficial in non-ketotic hyperglycinaemia.

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