• Clinics · Jan 2021

    Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions.

    • Tatiana Carvalho de Souza Bonetti, Flavia Roche Moreira Latini, Adriana Lukow Invitti, FonsecaMarcelo Cunio MachadoMCM0000-0003-0803-3715Laboratorio de Ginecologia Molecular, Departamento de Ginecologia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP, BR.Centro de Neurociencias e Saude da Mulher ", Fulvio Alexandre Scorza, Maira Garcia Saldanha, Fernanda T Bellucco, Natalia B S Bacarov, Michel M Soane, and Manoel João Batista Castelo Girão.
    • Laboratorio de Ginecologia Molecular, Departamento de Ginecologia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP, BR.
    • Clinics (Sao Paulo). 2021 Jan 1; 76: e2818.

    ObjectiveSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by high contagiousness, as well as variable clinical manifestations and immune responses. The antibody response to SARS-CoV-2 is directly related to viral clearance and the antibodies' ability to neutralize the virus and confer long-term immunity. Nevertheless, the response can also be associated with disease severity and evolution. This study correlated the clinical characteristics of convalescent COVID-19 patients with immunoglobulin A (IgA) and IgG anti-SARS-CoV-2 antibodies.MethodsThis study included 51 COVID-19 health care professionals who were candidates for convalescent plasma donation from April to June 2020. The subjects had symptomatic COVID-19 with a polymerase chain reaction-confirmed diagnosis. We measured anti-SARS-CoV-2 IgA and IgG antibodies after symptom recovery, and the subjects were classified as having mild, moderate, or severe symptoms.ResultsAnti-SARS-CoV-2 antibodies were positive in most patients (90.2%). The antibody indexes for IgA and IgG did not differ significantly between patients presenting with mild or moderate symptoms. However, they were significantly higher in patients with severe symptoms.ConclusionsOur study showed an association between higher antibody indexes and severe COVID-19 cases, and several hypotheses regarding the association of the antibody dynamics and severity of the disease in SARS-CoV-2 infection have been raised, although many questions remain unanswered.

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