• Edwina Landau, Huda Mussaffi, Vardit Kalamaro, Alexandra Quittner, Tammy Taizi, Diana Kadosh, Hadas Mantin, Dario Prais, Hannah Blau, and Meir Mei-Zahav.
• Pulmonary Institute, Schneider Children's Medical Center, Petah Tikva, Israel.
• Isr Med Assoc J. 2021 Sep 1; 23 (9): 584-589.

BackgroundAdherence to treatment by adolescents and adults with cystic fibrosis (CF) is often poor.ObjectivesTo assess the impact of a focused clinical intervention on adherence in individual patients, including help in problem-solving key barriers to adherence. To implement a patient-centered problem-solving intervention using CF My Way tools. To identify and overcome a selected barrier to adherence.MethodsMedication possession ratios (MPRs), number of airway clearance sessions, forced expiratory volume (FEV1), body mass index (BMI), and health-related quality of life (HRQoL) were measured before and after the intervention.ResultsSixteen patients with CF, aged 23.4 ± 6.7 years, participated. MPR increased for colistimethate sodium and tobramycin inhalations from a median of 21 (range 0-100) to 56 (range 0-100), P = 0.04 and 20 (range 0-100) to 33.3 (range 25-100), P = 0.03, respectively. BMI standard deviation score rose from -0.37 to -0.21, P = 0.05. No significant improvements were found in FEV1, airway clearance, or HRQoL scores.ConclusionsThe CF My Way problem-solving intervention increased adherence to medical treatments by removing barriers directly related to the needs and goals of young adults with CF.

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