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- Katia Vermoesen, Ilse Smolders, Ann Massie, Yvette Michotte, and Ralph Clinckers.
- Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
- Epilepsy Res. 2010 Jun 1; 90 (1-2): 164-6.
AbstractIn the present study the effectiveness of different diazepam-ketamine combinations to control kainic acid-induced status epilepticus in rats was evaluated. We show that electrographic monitoring is mandatory to enable reliable assessment of status epilepticus control as the number of false positives is extremely high when status epilepticus control is only behaviourally assessed. Diazepam and ketamine synergistically blocked all electrographical seizure activity.Copyright (c) 2010 Elsevier B.V. All rights reserved.
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