• Muhammad Nadeem Sajjad, Fatima Naumeri, and Sehrish Hina.
• Dr. Muhammad Nadeem Sajjad, MBBS. Department of Pediatric Surgery, King Edward Medical University/Mayo Hospital, Lahore, Pakistan.
• Pak J Med Sci. 2021 Sep 1; 37 (5): 1276-1281.

ObjectivesTo compare the outcome of non-operative treatment (NOT) with antibiotics versus surgical management of uncomplicated appendicitis in children.MethodsThis randomized clinical trial (NCT04030741) was carried out in Pediatric Surgery Department, Mayo Hospital from September 2018 to September 2019. Total sample size was 180, and after informed consent patients were randomly allocated in two groups. All children between 5 and 15 years of age and having pediatric appendicitis score (PAS) >7 were included. Patients with previous abdominal surgery, peritonitis, appendicular mass, or intra-abdominal abscess were excluded. Children in NOT group (Group A) were given intravenous Meropenem and Metronidazole for 48 hours and after starting oral, antibiotics were continued orally for 7 days. In Group B, children underwent appendectomy. Failure of NOT was labeled if there was abscess formation or peri-appendiceal fluid collection on ultrasound, development of peritonitis or recurrence of appendicitis.ResultsIn Group A, mean age was 9.56±1.8 years and in Group B 10.11±1.8 years. There were 123 male and 57 female patients. Group B had 100% successful outcome. NOT (Group A) had successful outcome in 75 patients (83.3%) and failure was noted in 15 (16.7%). Five needed operation within 48 hours, all had appendicolith, and 10 patients presented within 6 months. Raised total leukocyte count (p value < 0.0001) and C reactive protein (p value < 0.04) levels were noted with failure of NOT.ConclusionsIn this study, success of NOT was 84% so a trial of NOT in cases of uncomplicated appendicitis should be considered in children.Copyright: © Pakistan Journal of Medical Sciences.

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