• Internal medicine · Mar 2022

    Case Reports

    Recurrent Hypoglycemia Due to a High Titer of Insulin Antibody in Response to Exogenous Insulin Administration in Two Cases of Type 1 Diabetes.

    • Ryoichi Kawamura, Satoshi Miyao, Hiroshi Onuma, Yasuko Uchigata, Eiji Kawasaki, Jun Ohashi, Sanshiro Shiraishi, Wataru Nishida, Maki Yokomoto-Umakoshi, Yasunori Takata, Haruhiko Osawa, and Hideichi Makino.
    • Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Japan.
    • Intern. Med. 2022 Mar 1; 61 (5): 687695687-695.

    AbstractIn the first case, a 60-year-old man who was using continuous subcutaneous insulin infusion (CSII), developed recurrent hypoglycemia due to insulin antibodies. This is the first report of such a case using CSII. In the second case, a 70-year-old man was follow-up case who developed hypoglycemia while using human insulin. In both cases, the hypoglycemia subsided after switching to multiple daily insulin injection and/or insulin preparation. The results of Scatchard analyses of the two cases were similar to those of cases of insulin autoimmune syndrome (IAS) that improved after recovery from hypoglycemia.The clinical characteristics and Scatchard analysis data were essentially the same as those for IAS, except for the presence of insulin administration.

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