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- Yukino Katakura, Fuminori Tatsumi, Takashi Kusano, Masashi Shimoda, Kenji Kohara, Tomohiko Kimura, Atsushi Obata, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, and Hideaki Kaneto.
- Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.
- Intern. Med. 2022 Mar 15; 61 (6): 861864861-864.
AbstractA 58-year-old Japanese man was brought to the emergency room due to disturbance of consciousness. He regained consciousness on the day of admission and started taking hospital meals, but he needed intravenous glucose administration for eight days. The total amount of glucose administration was 4,464 g. It took over three weeks for exogenous insulin to be almost undetectable. While degludec binds to albumin and exerts glucose-lowering effects for a long time, the above-mentioned period of three weeks was consistent with the half-life of albumin. Hypoglycemia induced by massive dose of insulin degludec is persistent and prominent.
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