• Int. J. Clin. Pract. · Nov 2021

    Meta Analysis

    Crimean-Congo hemorrhagic fever-induced liver injury: a systematic review and meta-analysis.

    • Sawai Singh Rathore, Ade Harrison Manju, Qingqing Wen, Manush Sondhi, Reshma Pydi, Iskander Haddad, Jamal Hasan, Muhammad Adnan Ali, Sohaib Tousif, Romil Singh, Abdul-Azeez Muhammed, Noman Khurshid Ahmed, and Deep Manojkumar Patel.
    • Internal Medicine, Dr. Sampurnanand Medical College, Jodhpur, India.
    • Int. J. Clin. Pract. 2021 Nov 1; 75 (11): e14775.

    BackgroundCrimean-Congo haemorrhagic fever (CCHF) is a fatal acute tick-borne viral infection and substantial emerging global public health threat. This illness has a high case fatality rate of up to 40%. The liver is one of the important target organs of the CCHF virus.ObjectiveThe aim of this meta-analysis to evaluate the correlation between CCHF and liver injury and draw more generalised inferences about the abnormal serum markers of liver injury such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) in CCHF patients.MethodsA literature search was accomplished for published eligible articles with MEDLINE/PubMed and Embase databases. All eligible observational studies and case series were included from around the world. The inclusion criteria were articles describing liver injury biomarkers amongst patients diagnosed with CCHF.ResultsData from 18 studies, consisting of 1238 patients with CCHF were included in this meta-analysis. Overall pooled incidence of at least one raised liver injury biomarker was 77.95% (95% CI, I2  =  88.50%, P < .0001). Similarly, pooled incidence of elevated AST and ALT was 85.92% (95% CI, I2  = 85.27%, P < .0001) and 64.30% (95% CI, I2  =  88.32%, P < .0001), respectively. Both Egger and Begg-Mazumdar's tests detected no apparent publication bias in all three meta-analyses (P > .05).ConclusionOur study shows that CCHF has a very detrimental effect on liver function. Abnormal liver function may lead to poor prognosis and increased morbidity and mortality in CCHF patients. Hence, Physicians must recognise and continuously monitor these biomarkers, since these markers may aid in early stratification of prognosis and the prevention of severe outcomes in infection with such a high case fatality rate.© 2021 John Wiley & Sons Ltd.

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