• Int. J. Clin. Pract. · Nov 2021

    Potentially inappropriate medication use in elderly patients treated in intensive care units: a cross-sectional study using 2019 Beers, STOPP/v2 Criteria and EU(7)-PIM List.

    • Ferhan Demirer Aydemir, Seyma Oncu, Nuri M Yakar, Gokalp A Utkugun, Necati Gokmen, Bilgin Comert, Reyhan Ucku, and Ayse Gelal.
    • Division of Intensive Care Medicine, Department of Internal Medicine, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.
    • Int. J. Clin. Pract. 2021 Nov 1; 75 (11): e14802.

    ObjectiveTo determine the prevalence of and the risk factors for Potentially Inappropriate Medication (PIM), the drug groups most commonly evaluated as PIMs in elderly patients in the ICUs by using 2019 Beers Criteria, STOPP version 2 (v2) Criteria and EU(7)-PIM List. The relation between mortality rate and length of ICU stay with PIMs was also examined.MethodsThis was a cross sectional study conducted on patients aged ≥65 years, treated in ICUs (n = 139) between June 8, 2020, and January 11, 2021. Patients' demographic characteristics, clinical data and laboratory findings about the drugs used were collected prospectively. PIMs were evaluated according to each of the criteria applied. Relationship of dependent and independent variables was evaluated using chi-square analysis, t-test and logistic regression analysis. P < .05 was considered statistically significant.ResultsThe number of patients with at least 1 PIM according to three criteria was 118 (84.9%) (80.6%, 59.7%, 48.2%, Beers, STOPP/v2 and EU(7)-PIM List, respectively). In the univariate analysis, receiving renal replacement therapy and high number of drugs were the covariates that significantly affected the presence of PIM according to all three criteria (P < .05). Combined use of anxiolytics and opioids in Beers Criteria (58.3%), antipsychotics (26.6%) in STOPP/v2 Criteria, and antiarrhythmics (23.7%) in EU(7)-PIM List were the drugs that caused PIM at most. No relationship was found between the presence of PIM and mortality. The length of ICU stay was determined significantly longer in the presence of PIM according to Beers Criteria (P = .028).ConclusionsIn this study, the prevalence of PIM was determined higher in elderly patients in ICU. Our results supported that 2019 Beers Criteria for ICU patients seems to be more directive in detecting PIMs and determining the prognosis. Reducing the number of drugs administered may be the first step to decrease PIMs in elderly patients in ICU and to maintain the treatment safely.© 2021 John Wiley & Sons Ltd.

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