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- Laurens Nieuwenhuizen and Douwe H Biesma.
- Department of Internal Medicine, St. Antonius Hospital, Nieuwegein, The Netherlands. l.nieuwenhuizen@antonius.net
- Eur. J. Haematol. 2008 Jan 1;80(1):1-9.
AbstractInvolvement of the central nervous system (CNS) in multiple myeloma (MM) is very uncommon; it has been observed in approximately 1% of the MM patients. This review summarizes the clinical and laboratory characteristics and treatment modalities of 109 patients with CNS myelomatosis (CNS MM) reported in the literature. CNS MM has a wide spectrum of neurological symptoms and signs. No guidelines for therapy of CNS MM are available, which has resulted in a large variation in the treatment schedules. Treatment options include intrathecal chemotherapy (IT), systemic chemotherapy (SC), cranial irradiation (CI) or a combination. The prognosis of CNS MM remains poor, with an overall median survival from the time of diagnosis to death of 2.0 months (range 0.1-25 months). Patients who were treated with CI had a significantly (P = 0.004) longer survival when compared with patients without CI.
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