• Daphne F M Reukers, Michiel van Boven, Adam Meijer, Nynke Rots, Chantal Reusken, Inge Roof, Arianne B van Gageldonk-Lafeber, Wim van der Hoek, and Susan van den Hof.
• Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
• Clin. Infect. Dis. 2021 Apr 2.

BackgroundIndoor environments are considered one of the main settings for transmission of SARS-CoV-2. Households in particular represent a close-contact environment with high probability of transmission between persons of different ages and with different roles in society.MethodsComplete households with a laboratory-confirmed SARS-CoV-2 positive case in the Netherlands (March-May 2020) were included. At least three home visits were performed during 4-6 week of follow-up, collecting naso- and oropharyngeal swabs, oral fluid, feces and blood samples for molecular and serological analyses of all household members. Symptoms were recorded from two weeks before the first visit through to the final visit. Infection secondary attack rates (SAR) were estimated with logistic regression. A transmission model was used to assess transmission routes in the household.ResultsA total of 55 households with 187 household contacts were included. In 17 households no transmission took place, and in 11 households all persons were infected. Estimated infection SARs were high, ranging from 35% (95%CI: 24%-46%) in children to 51% (95%CI: 39%-63%) in adults. Estimated transmission rates in the household were high, with reduced susceptibility of children compared to adolescents and adults (0.67; 95%CI: 0.40-1.1).ConclusionEstimated infection SARs were higher than reported in earlier household studies, presumably owing to our dense sampling protocol. Children were shown to be less susceptible than adults, but the estimated infection SAR in children was still high. Our results reinforce the role of households as one of the main multipliers of SARS-CoV-2 infection in the population.© Infectious Diseases Society of America 2021.

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